Cu(II)/Photoredox-Catalyzed Aminoacylation of Vinyl Bromides
A novel C-C coupling reaction of vinyl bromides with carboxamides has been developed through Cu(OAc)<sub>2</sub>/photocatalysis. This process features regioselective carboxamido carbon-vinylation under mild reaction conditions. Mechanistic studies suggest that the formation of an acyl-Cu(I) intermediate plays a crucial role with regard to enabling this transformation.
Authors
- Wei Zeng (ORCID: https://orcid.org/0000-0002-6113-2459)
- Huanfeng Jiang (ORCID: https://orcid.org/0000-0002-4355-0294)
- Qiang Zeng (ORCID: https://orcid.org/0000-0002-6295-0656)
- Guojin Huang (ORCID: https://orcid.org/0000-0001-7020-5528)
Institutions
- Key Laboratory of Guangdong Province (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c01104
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province