The Involvement of Oral Pathogenic Bacteria, Fusobacterium nucleatum Subspecies animalis in the Pathogenesis of Human Esophageal Adenocarcinoma
Intratumoral microbiota, especially the infiltration of oral pathogenic bacteria such as <i>F. nucleatum</i>, has a profound impact on the tumor microenvironment of EAC. Spp. <i>animalis</i> was predominant among <i>F. nucleatum</i> in the EAC tissues and induced significant DNA damage in cancer cells.
Authors
- Shintaro Okumura (ORCID: https://orcid.org/0000-0002-1480-4101)
- Shigeru Tsunoda (ORCID: https://orcid.org/0000-0003-1468-7352)
- Tomonori Matsumoto (ORCID: https://orcid.org/0000-0003-4483-2178)
- Kazutaka Obama (ORCID: https://orcid.org/0000-0003-2924-6701)
- Teruaki Kitano
- Tatsuto Nishigori (ORCID: https://orcid.org/0000-0002-4969-5590)
- Eiji Hara (ORCID: https://orcid.org/0000-0001-7821-3960)
Institutions
- Kyoto University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100660
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Moonshot Research and Development Program