STUDY OF THE EFFECT OF TRIPTERYGIUM WILFORDII HOOK F EXTRACT ON THE LEVEL OF INTERLEKIN-17 SYNTHESIS IN THE CULTURE OF MONONUCLEAR CELLS OF ROSACEA PATIENTS

Background. Rosacea is a common skin disease, affecting up to 3% of the general population, the mechanisms of which are unclear. The etiopathogenetic factors of rosacea include microscopic mites of the genus Demodex and the proinflammatory cytokine interleukin-17. The inhibitory effect of Tripterygium Wilfordii Hook F plant extracts on proinflammatory cytokines, including IL-17, is also known. However, a comprehensive study of the relationship between these factors in rosacea has not been conducted yet. Purpose. To study changes in the level of interleukin-17 synthesis by mononuclear cells of healthy donors and rosacea patients in vitro in response to Demodex antigens and the modulating effect of Tripterygium Wilfordii extract. Materials and methods. The effect of Tripterygium Wilfordii extract on the level of spontaneous and Demodex antigen-stimulated interleukin-17 synthesis was determined in a cell culture of healthy donors and patients with different forms of rosacea. Results. A high level of spontaneous IL-17 synthesis by mononuclear cells of rosacea patients, a pronounced response to the Demodex antigen both in patients and healthy donors, as well as an unconditional inhibitory effect of Tripterygium Wilfordii Hook F extract were revealed. Conclusion. Tripterygium Wilfordii Hook F extract inhibits interleukin-17 synthesis by mononuclear cells of rosacea patients and healthy donors against the Demodex antigen.