A simple protocol for stereoselective construction of novel β-sulfanyl vinyl sulfonyl fluorides
The addition of thiols to 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) in the presence of an organic base has been successfully employed for the synthesis of highly functionalized sulfanyl vinyl sulfonyl fluorides. This reaction features a broad substrate scope, mild reaction conditions, high atom economy, good to excellent isolated yields of up to 100%, and remarkable stereoselectivity, making it valuable for applications in chemical biology and medicinal chemistry. Further product diversification resulted in the construction of enaminyl sulfonyl fluorides.
Authors
- Fayez Althobaiti (ORCID: https://orcid.org/0000-0002-8344-9238)
- Hanadi A. Katouah (ORCID: https://orcid.org/0000-0001-9044-2491)
- Eman Elsayed Fayad (ORCID: https://orcid.org/0000-0003-2916-0254)
- Hua‐Li Qin (ORCID: https://orcid.org/0000-0002-6609-0083)
- Monday Peter Ajisafe
- Heba H. Mohamedy
Institutions
- Taif University (SA)
- Wuhan University of Technology (CN)
- Umm al-Qura University (SA)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00029g
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.58
Funders
- Taif University