Pharmacokinetics of post-transplant cyclophosphamide and its associations with clinical outcomes in pediatric haploidentical hematopoietic stem cell transplantation
Our study provides insights into the pharmacokinetic profile of cyclophosphamide and its metabolite, carboxycyclophosphamide, in pediatric patients undergoing haploidentical HSCT with PTCy. The intricate interplay between pharmacokinetic parameters and post-HSCT complications suggests the need for tailored adjustments in PTCy dosage, particularly in pediatric patients subjected to myeloablative conditioning regimens.
Authors
- Jaeseong Oh (ORCID: https://orcid.org/0000-0001-6275-8587)
- Joo‐Youn Cho (ORCID: https://orcid.org/0000-0001-9270-8273)
- Yoon Sunwoo (ORCID: https://orcid.org/0000-0001-7444-7823)
- Jung Yoon Choi (ORCID: https://orcid.org/0000-0001-9534-0400)
- Hyoung Jin Kang (ORCID: https://orcid.org/0000-0003-1009-6002)
- Sungyeun Bae (ORCID: https://orcid.org/0000-0002-6584-9158)
- Ju‐Yeon Lee (ORCID: https://orcid.org/0000-0003-0653-7223)
- Hyun Jin Park (ORCID: https://orcid.org/0000-0003-4170-0890)
- Kyung Taek Hong (ORCID: https://orcid.org/0000-0002-6135-0480)
- Kyung-Sang Yu
- Bo Kyung Kim (ORCID: https://orcid.org/0000-0003-4671-0449)
Institutions
- Seoul National University (KR)
- Cancer Research Institute (US)
- Seoul National University Hospital (KR)
- Seoul National University Children's Hospital (KR)
- National University College (PR)
- Jeju National University Hospital (KR)
- Jeju National University (KR)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s40364-025-00749-3
- Citations
- 2
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- Ministry of Food and Drug Safety