Human umbilical cord mesenchymal stem cell-derived microvesicles alleviate pulmonary fibrosis by inhibiting monocyte‒macrophage migration through ERK1/2 signaling-mediated suppression of CCL2 expression
Our findings demonstrate that the protective effect of MSC-MVs against BLM-induced lung toxicity was achieved through the inhibition of the ERK1/2 signaling pathway, leading to the suppression of CCL2 expression and subsequent modulation of monocyte-macrophage migration, thereby establishing a theoretical basis for the effect of MSC-MVs in PF.
Authors
- Ziyi Tang
- Zehui Liao
- Yubin Luo (ORCID: https://orcid.org/0000-0002-7669-1579)
- Yinlan Wu (ORCID: https://orcid.org/0000-0002-0188-8676)
- Chunyu Tan (ORCID: https://orcid.org/0009-0004-1068-5995)
- Ren Liao (ORCID: https://orcid.org/0000-0002-4100-5268)
- Lu Cheng (ORCID: https://orcid.org/0000-0001-6624-5906)
- Yanhong Li (ORCID: https://orcid.org/0009-0003-8578-0623)
- Jing Zhao (ORCID: https://orcid.org/0009-0000-2888-7326)
- Xiuping Liang (ORCID: https://orcid.org/0000-0003-0555-0143)
- Tong Wu (ORCID: https://orcid.org/0009-0009-9647-0763)
- Deying Huang (ORCID: https://orcid.org/0000-0001-5891-4196)
- Yi Liu (ORCID: https://orcid.org/0009-0008-0541-8066)
Institutions
- Sichuan University (CN)
- Meizhou City People's Hospital (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s13287-025-04266-w
- Citations
- 5
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- Sichuan Youth Science and Technology Foundation
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program