Quantitative dried blood spot microsampling for therapeutic drug monitoring of -antiseizure medications by design of experiment and UHPLC-MS/MS
A UHPLC-MS/MS assay was developed and validated according to EMA guidelines for quantifying ASMs from qDBS devices. This validation has the advantage of allowing the potential to utilize the new microsampling qDBS device, providing a patient-friendly approach to blood sampling eventually even at-home.
Authors
- Chiara Cancellerini (ORCID: https://orcid.org/0000-0002-7637-2404)
- Francesca Bisulli (ORCID: https://orcid.org/0000-0002-1109-7296)
- Jessica Fiori (ORCID: https://orcid.org/0000-0002-6004-5118)
- Alessandra Merlotti (ORCID: https://orcid.org/0000-0002-3648-2828)
- Barbara Mostacci (ORCID: https://orcid.org/0000-0002-6994-0821)
- Luca Vignatelli (ORCID: https://orcid.org/0000-0002-9051-7091)
- Nicolas Riccardo Derus (ORCID: https://orcid.org/0000-0002-3616-9153)
- Laura Maria Beatrice Belotti (ORCID: https://orcid.org/0000-0002-5828-6780)
- Laura Licchetta (ORCID: https://orcid.org/0000-0001-7979-9895)
- Erika Esposito (ORCID: https://orcid.org/0009-0000-4901-7960)
- Martina Soldà
- Alice Caravelli
- Francesco Casadei (ORCID: https://orcid.org/0009-0006-0789-546X)
Institutions
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Talanta
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1016/j.talanta.2025.128018
- Citations
- 3
- Primary Topic
- Biosimilars and Bioanalytical Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.39