Quantitative Optimization of the Heating Element for Enhanced Temperature Uniformity in an Embryo Chamber
In assisted reproductive technology (ART), maintaining a uniform and stable temperature field within the culture space is critical for ensuring consistent embryo development quality. Traditional heating methods often overlook the inherent heat transfer characteristics of the system, resulting in significant temperature gradients across the culture space. This study introduces a quantitative optimization approach for the heating element, focusing on metal foil as a case study, to enhance temperature uniformity in the embryo chamber. We employ numerical simulation techniques to analyze the temperature distribution of the cultivation chamber based on the layout of the heating elements. After the chamber achieves heat transfer equilibrium, we segment the culture chamber structure into multiple isothermal regions and apply the law of energy conservation to establish a mathematical relationship between the changes in heating element resistance and temperature within each region. By iteratively adjusting the length or width of the metal foil in different areas, we optimize the temperature distribution of the overall structure, thereby improving the uniformity of the temperature field within the embryo chamber. The experimental results indicate that the optimized heating element reduces the temperature gradient within the culture chamber from 0.5 °C to less than 0.1 °C, providing robust technical support for enhancing embryo development quality and consistency.
Authors
- Yu Song (ORCID: https://orcid.org/0000-0002-8610-0525)
- Zhenying Zhao
- Weijun Zeng (ORCID: https://orcid.org/0000-0003-2994-9810)
- Haixuan Sun (ORCID: https://orcid.org/0009-0009-6454-7156)
- Donggen Xiao
Institutions
- Chinese Academy of Sciences (CN)
- Suzhou Institute of Biomedical Engineering and Technology (CN)
Publication Details
- Journal
- Symmetry
- Published
- 2025-03-22
- DOI
- https://doi.org/10.3390/sym17040478
- Citations
- 1
- Primary Topic
- Additive Manufacturing Materials and Processes
- Type
- article
- Field-Weighted Citation Impact
- 0.71
Funders
- National Key Research and Development Program of China