AID/APOBEC: an expanding repertoire of targets and functions
Deaminases belonging to the AID/APOBEC family are known as ssDNA and mRNA mutators involved in innate/adaptive immunity, mRNA editing, genome stabilization by restricting retrotransposons, and carcinogenesis. Recent studies suggest that the repertoire of AID/APOBEC targets is more diverse than previously thought and imply a broader biological impact of these proteins.
Authors
- Marek Figlerowicz (ORCID: https://orcid.org/0000-0002-6392-0192)
- Lucyna Budzko (ORCID: https://orcid.org/0000-0003-4082-3370)
- Aleksandra Mierzwa
Institutions
- InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (PL)
Publication Details
- Journal
- Trends in Biochemical Sciences
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1016/j.tibs.2025.02.006
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Badań i Rozwoju