Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis
TREM2 is elevated in melanoma-associated macrophages of aged mice and humans and can be inhibited to block melanoma metastasis, highlighting the role of the microenvironment in promoting aging-related metastasis.
Authors
- Peter D. Adams (ORCID: https://orcid.org/0000-0002-0684-1770)
- Alexey V. Terskikh (ORCID: https://orcid.org/0000-0003-4641-3997)
- Yongmei Feng (ORCID: https://orcid.org/0000-0001-6813-5567)
- Rabi Murad (ORCID: https://orcid.org/0009-0004-5297-8307)
- Ze’ev A. Ronai (ORCID: https://orcid.org/0000-0002-3859-0400)
- Parinaz Bina (ORCID: https://orcid.org/0000-0003-1488-5017)
- Rebecca A. Porritt (ORCID: https://orcid.org/0000-0002-0973-5092)
- Marzia Scortegagna (ORCID: https://orcid.org/0009-0006-0788-3194)
- Xiao Tian (ORCID: https://orcid.org/0000-0001-5300-3596)
- Kristiina Vuori (ORCID: https://orcid.org/0000-0002-5657-0681)
Institutions
- Cedars-Sinai Medical Center (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Discovery Institute (US)
- University of California San Diego (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4317
- Citations
- 9
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- National Institute on Aging
- National Cancer Institute