Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells
Increased expression of α-SMA, FN-EDA, N-cadherin, SNAI2, TWISTs, VIM, TGFβ signaling, and MMP activity are consistent with GTM cells acquiring an EndMT phenotype. In combination with tissue studies, cultured GTM cells are a useful in vitro model for studying the fibrotic process in glaucoma.
Authors
- Jennifer A. Faralli
- Donna M. Peters (ORCID: https://orcid.org/0000-0002-1303-7027)
- Kate E. Keller (ORCID: https://orcid.org/0000-0002-1616-972X)
- Ying Sun (ORCID: https://orcid.org/0000-0002-1444-5057)
- Paul Holden
- Yong-Feng Yang
Institutions
- University of Wisconsin–Madison (US)
- Oregon Health & Science University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1167/iovs.66.3.48
- Citations
- 4
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.83