Rosuvastatin restores liver tissue-resident NK cell activation in aged mice by improving mitochondrial function
Our study demonstrates age-related cholesterol accumulation in trNK cells correlated with senescence and functional impairment. Rosuvastatin is suggested to boost, rejuvenate and recover NK cell functionality.
Authors
- Johnny Amer (ORCID: https://orcid.org/0000-0001-5828-6783)
- Rifaat Safadi (ORCID: https://orcid.org/0000-0002-8689-5217)
- Ahmad Salhab
Institutions
- Hebrew University of Jerusalem (IL)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1016/j.biopha.2025.118000
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.99