Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human precision-cut lung slices
In summary, our findings suggest that aged lung tissue might not favor viral dissemination, pointing to a determinant role of dysregulated immune mechanisms in the development of severe disease.
Authors
- Gert Zimmer (ORCID: https://orcid.org/0000-0002-2708-2507)
- Marco P. Alves (ORCID: https://orcid.org/0000-0002-8495-6098)
- Carlos Machahua (ORCID: https://orcid.org/0000-0003-4964-7393)
- Manuela Funke-Chambour (ORCID: https://orcid.org/0000-0003-3417-5872)
- Damian Jandrasits
- Patrick Dorn (ORCID: https://orcid.org/0000-0002-7203-3122)
- Blandina I. Oliveira Esteves
- Melanie Brügger (ORCID: https://orcid.org/0000-0003-3810-7682)
- Sameera Ezzat (ORCID: https://orcid.org/0000-0003-3927-401X)
- Bettina Salome Trüeb (ORCID: https://orcid.org/0000-0001-7256-9245)
- Thomas M. Marti (ORCID: https://orcid.org/0000-0003-3005-220X)
- Volker Thiel (ORCID: https://orcid.org/0000-0002-5783-0887)
- Christiana Cismaru (ORCID: https://orcid.org/0009-0000-7591-6652)
- Trix Zumkehr (ORCID: https://orcid.org/0009-0002-3614-4930)
Institutions
- University of Bern (CH)
- Spiez Laboratory (CH)
- University Hospital of Bern (CH)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12931-025-03190-0
- Citations
- 6
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- Bern Center for Precision Medicine, University of Bern