Sodium tanshinone IIA sulfonate promotes proliferation and differentiation of endogenous neural stem cells to repair rat spinal cord injury via the Notch pathway
STS promotes the proliferation of ENSCs post-SCI in rats, induces their differentiation into neurons, and inhibits their differentiation into astrocytes, thereby improving the pathological morphology of the injured spinal cord and promoting the recovery of hindlimb motor function in rats post-SCI. Furthermore, the regulatory effects of STS on the proliferation and differentiation of ENSCs post-SCI in rats may be related to its inhibition of the excessive activation of the Notch signaling pathway.
Authors
- Yushan Gao (ORCID: https://orcid.org/0000-0003-4469-0720)
- Yukun Ma
- Yongdong Yang (ORCID: https://orcid.org/0000-0002-1732-7742)
- Jiaojiao Fan (ORCID: https://orcid.org/0009-0002-2648-2813)
- Guozheng Jiang (ORCID: https://orcid.org/0000-0002-6336-3795)
- Luchun Xu
- Shibo Zhou (ORCID: https://orcid.org/0000-0003-1260-0807)
- Wenhao Li (ORCID: https://orcid.org/0000-0003-0717-9069)
- Jiawei Song (ORCID: https://orcid.org/0009-0006-7338-8917)
- Wenqing Zhong
- Guanlong Wang
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12967-025-06331-7
- Citations
- 1
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China