The olfactory receptor OR51E2 regulates prostate cancer aggressiveness and modulates STAT3 in prostate cancer cells and in xenograft tumors
OR51E2 is regulated throughout prostate cancer progression and actively influences cancer cell physiology affecting cancer aggressiveness. Reduced OR51E2 expression may adversely affect patient outcomes, potentially through alterations in the STAT3 pathway that impact cellular responses to inflammatory signaling.
Authors
- Sharon J. Pitteri (ORCID: https://orcid.org/0000-0002-3119-873X)
- Hongjuan Zhao (ORCID: https://orcid.org/0000-0001-6083-0370)
- James D. Brooks (ORCID: https://orcid.org/0000-0003-4521-7505)
- Morten Busk (ORCID: https://orcid.org/0000-0001-5711-1017)
- Jens Randel Nyengaard
- Mikkel Thy Thomsen (ORCID: https://orcid.org/0000-0001-6515-675X)
- Chun-Lung Chiu (ORCID: https://orcid.org/0000-0001-7514-9676)
- Michael Borre (ORCID: https://orcid.org/0000-0002-1519-9185)
- Fernando Jose Garcia-Marques (ORCID: https://orcid.org/0000-0002-2105-2905)
- Dalin Zhang (ORCID: https://orcid.org/0000-0002-5869-6544)
- Abel Bermudez (ORCID: https://orcid.org/0009-0002-3235-5538)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Stanford University (US)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12885-025-13928-0
- Citations
- 6
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.79
Funders
- Novo Nordisk Fonden
- National Institutes of Health