The Impact of Weight Categories on the Association Between Atrial Fibrillation/Flutter and Known Risk Factors: A Nationwide Inpatient Data Analysis

<b>Background/Objectives</b>: Atrial fibrillation and atrial flutter (Afib/Aflut) are the most common arrhythmias presenting to the emergency department. The goal of this study was to evaluate any predictor of Afib/flut with cardiovascular risk factors and demographics based on weight categories. <b>Methods</b>: Using ICD-10 codes from the large Nationwide Inpatient Sample (NIS) database in the years 2016-2020, we evaluate any association between the presence of Afib/Aflut with risk factors and demographics in different weight categories in adults over the age of 18. <b>Results</b>: A total of 23,037,013 afib/flut patients were found in the NIS database. Obesity and morbid obesity were independently associated with the presence of Afib/Aflut (for multivariate OR obesity: 1.28, CI 1.27-1.28, <i>p</i> < 0.001; for morbid obesity: OR 1.9, CI 1.89-1.91, <i>p</i> < 0.001). Regardless of weight categories such as cachexia, overweight, obese, or morbidly obese, traditional risk factors remained independently associated with Afib/Aflut. Furthermore, male gender and Caucasians were independently associated with the presence of Afib/Aflut regardless of any weight categories. (For example, in the overweight categories, the multivariate OR for females was 0.69, CI: 0.69-0.69, <i>p</i> < 0.001, and for African Americans, OR 0.62, CI 0.61-0.62, <i>p</i> < 0.001). <b>Conclusions</b>: Traditional risk factors were persistently associated with the occurrence of atrial fibrillation regardless of weight categories. Furthermore, the Caucasian race and male gender were also strong independent predictors of Afib/Aflut.