Comprehensive multiomics analysis identifies PYCARD as a key pyroptosis-related gene in osteoarthritis synovial macrophages
PYCARD was identified as the core pyroptosis gene in OA macrophages, and 57 potential therapeutic compounds were identified. This study offers valuable insights into potential treatment targets for OA.
Authors
- Daozhang Cai (ORCID: https://orcid.org/0000-0002-9375-7859)
- Yuexin Li (ORCID: https://orcid.org/0000-0001-8525-2853)
- Zhuolun Wang
- Zihao Yao
- H. Mai (ORCID: https://orcid.org/0000-0002-4054-0429)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0002-9361-3134)
- Xiangjiang Wang (ORCID: https://orcid.org/0000-0002-6681-4934)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1558139
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22