Endothelial-like cancer-associated fibroblasts facilitate pancreatic cancer metastasis via vasculogenic mimicry and paracrine signalling
FAPα<sup>+</sup>CD144<sup>+</sup>endoCAFs can promote metastasis of PDAC via undertaking VM and paracrine through activation of the CD144-β-catenin-STAT3 signalling axis. CAF-targeting siRNA delivery nanosystem can inhibit tumour progression by precisely targeting FAPα<sup>+</sup>CD144<sup>+</sup>endoCAFs.
Authors
- Chuntao Gao (ORCID: https://orcid.org/0000-0002-9954-8409)
- Tiansuo Zhao (ORCID: https://orcid.org/0000-0003-1631-6299)
- Yu Guo (ORCID: https://orcid.org/0000-0003-3541-8282)
- Danqi Fu
- Shengyu Yang (ORCID: https://orcid.org/0000-0003-2390-243X)
- Haorui Li (ORCID: https://orcid.org/0009-0004-5336-4876)
- Xugang Sun
- Zhaoyu Zhang
- Jihui Hao (ORCID: https://orcid.org/0000-0002-1607-1730)
- Yifei Wang (ORCID: https://orcid.org/0000-0002-2073-2837)
- Yukuan Feng
- Xi Ma
- Wenrun Cai
- Di Xiao (ORCID: https://orcid.org/0000-0003-3686-8226)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Gut
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1136/gutjnl-2024-333638
- Citations
- 18
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 14.35
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China