Dietary whey protein protects against Crohn’s disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome
Our study charted the importance of cross-kingdom interaction between gut phage and bacteria in mediating the dietary effect on CD protection. Importantly, we uncovered a beneficial dietary WP, a keystone phage AkkZT003P, and a probiotic <i>S. thermophilus</i> that can be used in CD management in the future.
Authors
- Zhiyang Feng (ORCID: https://orcid.org/0009-0009-8057-0217)
- Ping Lan (ORCID: https://orcid.org/0000-0002-8901-8498)
- Hu Zhang (ORCID: https://orcid.org/0000-0002-3281-4661)
- Xiang Gao (ORCID: https://orcid.org/0000-0002-3058-4655)
- Shanshan Gao (ORCID: https://orcid.org/0000-0003-1209-3403)
- Jie Chen (ORCID: https://orcid.org/0000-0002-4029-4192)
- Lu Yu (ORCID: https://orcid.org/0000-0002-8873-9138)
- Weijie Wen (ORCID: https://orcid.org/0000-0003-4791-8516)
- Runping Su
- Kang Chao (ORCID: https://orcid.org/0000-0003-2342-0422)
- Tao Zuo (ORCID: https://orcid.org/0000-0001-8450-5281)
- Yufeng Jin
- Anna Philips (ORCID: https://orcid.org/0000-0001-5020-8836)
- Zhirui Cao
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Kun Li (ORCID: https://orcid.org/0000-0002-8119-5692)
- Fen Zhang (ORCID: https://orcid.org/0000-0003-0887-1073)
- Xiaojian Wu (ORCID: https://orcid.org/0000-0001-5610-2530)
- Chao Dong (ORCID: https://orcid.org/0000-0002-7645-2025)
- Guozhong Zhou
Institutions
- Central South University (CN)
- Shandong University (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (PL)
- Shandong Provincial QianFoShan Hospital (CN)
- Third Xiangya Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1136/gutjnl-2024-334516
- Citations
- 11
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 18.88
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province