Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling
Photocatalytic biomolecular labelling is gaining attention as a foundational technique for analyzing biological phenomena. However, photocatalytic reactions compatible with physiological conditions remain limited. Here, we present a photocatalytic reaction of diaryltetrazoles to generate nitrile imines, which readily couple with carboxylic acids in aqueous environments. This reaction is applied for photocatalyst-dependent labelling of proteins and cells.
Authors
- Yasushi Ishihama (ORCID: https://orcid.org/0000-0001-7714-203X)
- Takuro Matsuoka
- Hiroaki Ohno (ORCID: https://orcid.org/0000-0002-3246-4809)
- Norihito Arichi (ORCID: https://orcid.org/0000-0003-3618-4959)
- Kosuke Ogata (ORCID: https://orcid.org/0000-0002-0634-3990)
- Shinsuke Inuki (ORCID: https://orcid.org/0000-0002-7525-1280)
- Hideaki Kakeya (ORCID: https://orcid.org/0000-0002-4293-7331)
- Hiroki Akiba (ORCID: https://orcid.org/0000-0002-1450-5873)
- Akira Hattori (ORCID: https://orcid.org/0000-0001-5509-2326)
- Ryosuke Takasaki
- Sho Yamasaki (ORCID: https://orcid.org/0000-0002-5184-6917)
Institutions
- Kyoto University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Tokushima University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4cc04452e
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Science and Technology Corporation
- Japan Society for the Promotion of Science