Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead
[FeFe]-hydrogenases are highly-active hydrogen-conversion biocatalysts using Earth-abundant metals in their active-site. Understanding their mechanism may enable design of catalysts for renewable energy storage. Here, observation of the crucial Fe-hydride-containing (H<sub>hyd</sub>) intermediate in a PDT-variant of [FeFe]-hydrogenase reveals deeper insight into the role of the dithiolate bridgehead in the catalytic mechanism.
Authors
- Simone Morra (ORCID: https://orcid.org/0000-0003-1341-191X)
- Patricia Rodríguez‐Maciá (ORCID: https://orcid.org/0000-0003-3513-0115)
- James A. Birrell (ORCID: https://orcid.org/0000-0002-0939-0573)
- Manon T. Lachmann
- Anjali Depala
Institutions
- University of Essex (GB)
- University of Nottingham (GB)
- University of Leicester (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00860c
- Primary Topic
- Metalloenzymes and iron-sulfur proteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Essex
- Royal Society
- Royal Society of Chemistry
- University of Leicester
- Faculty of Engineering, University of Nottingham