Dietary emulsifier carboxymethylcellulose-induced gut dysbiosis and SCFA reduction aggravate acute pancreatitis through classical monocyte activation
This study reveals the detrimental impact of CMC on AP due to gut dysbiosis, with Akkermansia muciniphila or butyrate offering potential therapeutic avenues for counteracting CMC-induced AP exacerbation. Video Abstract.
Authors
- Fanyang Kong
- Shouxin Wu
- Jiayu Chen (ORCID: https://orcid.org/0000-0001-9396-0059)
- Lei Li (ORCID: https://orcid.org/0000-0003-4368-8637)
- Yiqi Du (ORCID: https://orcid.org/0000-0002-4261-6888)
- Feng-yuan Sun (ORCID: https://orcid.org/0000-0002-6554-491X)
- Yating Zhao (ORCID: https://orcid.org/0009-0004-3809-082X)
- Xiangyu Kong (ORCID: https://orcid.org/0000-0001-7293-4484)
- Wenjin Chen (ORCID: https://orcid.org/0009-0007-8511-7572)
- Yongpu Feng
- Zhao‐Shen Li
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- Naval University of Engineering (CN)
- XinHua Hospital (CN)
- Shanghai CASB Biotechnology (China) (CN)
- Changhai Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Institute of Infection and Immunity (CA)
Publication Details
- Journal
- Microbiome
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s40168-025-02074-1
- Citations
- 10
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China