IS26 carrying blaKPC−2 mediates carbapenem resistance heterogeneity in extensively drug-resistant Klebsiella pneumoniae isolated from clinical sites
This study reveals the key role of IS26-mediated transposition activity, through homologous recombination, in the emergence of carbapenem resistance heterogeneity in clinical K. pneumoniae strains carrying bla<sub>KPC-2</sub>. IS26 is able to promote the evolution of resistance in the IncFII plasmid, and through copy-in cointegration or targeted conservative cointegration may result in the acquisition or loss of antibiotic resistance, which may affect clinical care and pose a public health risk.
Authors
- Lingling Wu (ORCID: https://orcid.org/0000-0001-8738-0357)
- Mengfan Yue
- Zhiyun Guo (ORCID: https://orcid.org/0009-0008-7258-0805)
- Ning Li (ORCID: https://orcid.org/0000-0003-3880-5464)
- Qin Xia
- Meijie Jiang (ORCID: https://orcid.org/0000-0003-4041-7831)
- Jing Su (ORCID: https://orcid.org/0000-0001-9845-8084)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Zoucheng People's Hospital (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Mobile DNA
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s13100-025-00351-2
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77