Gastrodin Alleviates Tau Pathology by Targeting the Alzheimer's Risk Gene <scp>FERMT2</scp>, Reversing the Reduction in Brain Viscoelasticity
Gastrodin treatment has the potential to mitigate tau pathology, thereby enhancing learning and memory in AD mouse models. This effect may be mediated through the modulation of cerebral mechanical viscoelasticity via the mechanosensor FERMT2, which facilitates the restoration of synaptic structure and function. This process is potentially linked to the maintenance of BBB integrity and the modulation of inflammatory factor release.
Authors
- Xiaolan Qi (ORCID: https://orcid.org/0000-0002-9108-6772)
- Ting Sun (ORCID: https://orcid.org/0000-0002-2486-6146)
- Yang Wang (ORCID: https://orcid.org/0000-0003-4357-7451)
- Li Wang (ORCID: https://orcid.org/0000-0002-8009-9746)
- Bo Li (ORCID: https://orcid.org/0000-0002-0154-3088)
- Zhi Tang (ORCID: https://orcid.org/0000-0002-1670-9183)
- Anni Zhang (ORCID: https://orcid.org/0000-0003-1203-2993)
- Yaqian Peng
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Institute of Endemic Disease Control in Shandong Province (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70283
- Citations
- 1
- Primary Topic
- Biological and pharmacological studies of plants
- Type
- article
- Field-Weighted Citation Impact
- 1.39