Sorbicitrinols A and B, Two Sorbicillinoids with Unprecedented Skeletons Uncovered from Sponge-Derived Fungus <i>Penicillium</i> sp. S4I4-3 by a Molecular Networking Strategy
Sorbicitrinol A (<b>1</b>) and its biosynthetic precursor sorbicitrinol B (<b>2</b>), two novel sorbicillinoids with unprecedented skeletons, were isolated from the sponge-derived fungus <i>Penicillium</i> sp. by molecular networking. Their structures were identified by spectroscopic analyses and quantum chemistry. Both of them exhibited an innovative fusion pattern of sorbicillinol and a citrinin derivative. Compound <b>1</b> was the first example of a sorbicillinoid featuring the unique cage-like 2,5-dioxa-pentacyclo[10.4.0<sup>3,11</sup>.0<sup>4,8</sup>.0<sup>4,15</sup>]tetradecane scaffold. Plausible biogenetic pathways were proposed, and their antitumor and antifungal activities were also evaluated.
Authors
- Bing‐Xin Zhao (ORCID: https://orcid.org/0000-0003-0825-5211)
- Dai‐Chun Li
- Z P Chen
- Xiaojian Liao
- Hui-Xian Liang
- Wan‐Ying Guo
- Guo‐Dong Chen (ORCID: https://orcid.org/0000-0002-6773-4063)
- Shi‐Hai Xu (ORCID: https://orcid.org/0000-0001-8196-7667)
Institutions
- Jinan University (CN)
- Wuyi University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c00595
- Citations
- 7
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 9.76
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities