Advances in the Preparation, Structure-Activity Relationship, and Biological Mechanisms of <em>Agaricus</em> Polysaccharides

Polysaccharides derived from the <em>Agaricus</em> genus have garnered considerable attention due to their diverse biological activities and potential applications in functional foods and pharmaceuticals. This review focuses on the preparation methods, structure-activity relationships, and underlying biological mechanisms of <em>Agaricus</em> polysaccharides. Key advances in their extraction and purification techniques, structural characterization using modern analytical tools, and their association with biological activities are discussed. The role of polysaccharide structure, including glycosidic linkages, branching degrees, and molecular weight, in determining their physicochemical properties and biofunctions is highlighted. Moreover, the biological mechanisms underpinning their antitumor, immunomodulatory, antioxidant effects are elaborated. Finally, future perspectives on the challenges and opportunities for developing <em>Agaricus</em> polysaccharides as functional biomaterials are provided.

Authors

Publication Details

Journal
Food Science and Human Wellness
Published
2025-03-01
DOI
https://doi.org/10.26599/fshw.2025.9250590
Citations
2
Primary Topic
Fungal Biology and Applications
Type
article
Field-Weighted Citation Impact
2.79

Funders

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article

Advances in the Preparation, Structure-Activity Relationship, and Biological Mechanisms of Agaricus Polysaccharides

Jianzhao Qi, Ming Zhang, Yuying Liu, Minglei Li et al.
2 citations
Food Science and Human Wellness
Fungal Biology and Applications
2.79
article

Advances in the Preparation, Structure-Activity Relationship, and Biological Mechanisms of Agaricus Polysaccharides

Jianzhao Qi, Ming Zhang, Yuying Liu, Minglei Li, Zhixuan Li
article en
2 citations

Abstract

Polysaccharides derived from the <em>Agaricus</em> genus have garnered considerable attention due to their diverse biological activities and potential applications in functional foods and pharmaceuticals. This review focuses on the preparation methods, structure-activity relationships, and underlying biological mechanisms of <em>Agaricus</em> polysaccharides. Key advances in their extraction and purification techniques, structural characterization using modern analytical tools, and their association with biological activities are discussed. The role of polysaccharide structure, including glycosidic linkages, branching degrees, and molecular weight, in determining their physicochemical properties and biofunctions is highlighted. Moreover, the biological mechanisms underpinning their antitumor, immunomodulatory, antioxidant effects are elaborated. Finally, future perspectives on the challenges and opportunities for developing <em>Agaricus</em> polysaccharides as functional biomaterials are provided.

Food Science and Human Wellness
Yakult Bio-Science Foundation, National Key Research and Development Program of China
Zero hunger
Openalex Percentile: Top 12%
Fungal Biology and Applications
2.79
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Advances in the Preparation, Structure-Activity Relationship, and Biological Mechanisms of <em>Agaricus</em> Polysaccharides — Jianzhao Qi, Ming Zhang, et al. · Food Science and Human Wellness (2025) | TGRS Research Map | TGRS