Surface display of Lys0859, a Streptococcus suis prophage lysin, on Bacillus subtilis spores and its antibacterial activity against Streptococcus suis
This study achieved functional display of prophage lysin Lys0859 on <i>B. subtilis</i> spores through CotG anchoring, demonstrating potent <i>in vitro</i> anti-streptococcal activity. Crucially, this strategy streamlined bioproduction by eliminating purification demands and lowering costs, lays the foundation for the clinical application of prophage lysin.
Authors
- Mengyuan Zhu (ORCID: https://orcid.org/0000-0001-6047-8557)
- Dayue Hu (ORCID: https://orcid.org/0000-0002-7303-4709)
- Xiaochao Duan
- Linkang Wang (ORCID: https://orcid.org/0000-0003-1275-8663)
- Xinxin Li (ORCID: https://orcid.org/0000-0001-6336-9196)
- Xiangmin Li (ORCID: https://orcid.org/0000-0003-1412-5069)
- Haiyan Wang (ORCID: https://orcid.org/0000-0002-5759-4183)
- Ping Qian
Institutions
- Huazhong Agricultural University (CN)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1519935
- Citations
- 1
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88