Association of lysyl oxidase expression with clinicopathological features in colorectal adenocarcinomas
The current study indicates that LOX may be an important contributor to CRC progression. The findings of this series, in which LOX expression correlated with tumor budding and survival, support a contribution for LOX to EMT and metastasis. Furthermore, LOX expression in both the tumor cell and stromal compartment may add information to improve prognosis in CRC management. These findings, however, have to be validated in further studies, as does also the investigation of LOX as a potential therapeutic target in CRC.
Authors
- Ayça Çağlayan (ORCID: https://orcid.org/0000-0002-8644-0765)
- Ayşegül Aksoy Altınboğa (ORCID: https://orcid.org/0000-0003-1484-7619)
- Seda Kahraman (ORCID: https://orcid.org/0000-0002-5328-6554)
- Hayriye Tatlı Doğan (ORCID: https://orcid.org/0000-0003-4318-2775)
- Mustafa Tahtacı (ORCID: https://orcid.org/0000-0003-4046-3715)
- Doğukan Çanakçı (ORCID: https://orcid.org/0009-0000-9357-3761)
Institutions
- Ankara University (TR)
- Ege University (TR)
- Ankara Yıldırım Beyazıt University (TR)
Publication Details
- Journal
- International Journal of Colorectal Disease
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1007/s00384-025-04852-7
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.00