EFFECTS OF AVOCADO LEAF ETHANOL EXTRACT (Persea americana Mill.) AGAINST BLOOD SUGAR LEVELS, INTERLEUKIN-6 (IL-6), FGF AND WOUND AREA IN WHITE RATS WISTAR STRAIN (Rattus novergius sp.) DIABETIC ULCER MODEL

Diabetes mellitus (DM) is a global health problem, with the incidence of diabetic foot ulcers (UKD) on the rise. Patients with diabetes are prone to infections due to neuropathy, vascular insufficiency, and pre-existing neutrophil dysfunction. UKD is caused by poor circulation associated with peripheral neuropathy and peripheral vascular disease, increasing the risk of infection. The purpose of this study was to test the effect of avocado leaf ethanol extract on blood sugar levels, Interleukin-6 (IL-6), FGF, and wound area in diabetic ulcer models in rats. The study used a true experimental design with a post-test randomized control group, measuring the effect of the treatment on the experimental group compared to the control. The study was conducted from September to November 2023 for about 60 days. Samples included male Wistar mice that met inclusion criteria for age, weight, sex, and health conditions. The results showed the presence of flavonoids, phenols, saponins, tannins, and alkaloids in the study. Although there were significant differences in body weight between the study groups, there were no significant differences in blood sugar, IL-6, and FGF levels. The group that received avocado leaf ethanol extract at a dose of 100mg/kgBB showed better weight control, decreased blood sugar levels, anti-inflammatory effects, ulcer wound repair, and healing process. Suggestions for future research include immunohistochemical examination of ulcer wound tissue, follow-up research on patients with diabetic ulcers using herbal treatment from avocado leaf extract, as well as the use of these data as a reference for basic biomolecular research and histopathological examination.