Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer’s disease
Aβ-induced neuroinflammation is accompanied by enhanced levels of orexin-A and orexinergic neuron excitability. These findings suggest that the enhanced functionality of the orexinergic system may become a compensatory neuroprotective mechanism to counteract neuroinflammation and enhance cognitive function.
Authors
- Chao Zhuang (ORCID: https://orcid.org/0000-0002-1014-3369)
- Yifan Zhou (ORCID: https://orcid.org/0000-0002-3768-9353)
- Yanqing Liu (ORCID: https://orcid.org/0000-0001-6812-2811)
- Yan Li (ORCID: https://orcid.org/0000-0002-0255-0503)
- Hengyu Yan
- Guanglu Shi (ORCID: https://orcid.org/0000-0001-5562-111X)
- Jiayu Lu
Institutions
- Guiyang Medical University (CN)
- Guizhou University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fphys.2025.1529981
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Guizhou Province