Polyunsaturated fatty acids and their endocannabinoid-related metabolites activity at human TRPV1 and TRPA1 ion channels expressed in HEK-293 cells
PUFAs alone and their combined form in 9:3:1 ratio stimulate TRPA1 activity, whereas their metabolites trigger both TRPV1 and TRPA1 response. These findings suggest new avenues to explore for research into potential mechanisms underlying the neurological benefits of PUFAs and their metabolites.
Authors
- Mark Connor (ORCID: https://orcid.org/0000-0003-2538-2001)
- Alfonso E. Garcia‐Bennett (ORCID: https://orcid.org/0000-0002-9097-0179)
- Marina Santiago (ORCID: https://orcid.org/0000-0001-9388-8309)
- Atnaf Alebie Abate (ORCID: https://orcid.org/0000-0003-0945-5135)
Institutions
- Australian Research Council (AU)
- Macquarie University (AU)
Publication Details
- Journal
- PeerJ
- Published
- 2025-03-24
- DOI
- https://doi.org/10.7717/peerj.19125
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39