Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension
The PKC/IRS-1/ERK signaling pathway is implicated in the abnormal proliferation and migration of PASMCs, contributing to pulmonary vascular remodeling in PAH. Targeting this pathway through PKC inhibition or IRS-1 stabilization may offer novel therapeutic strategies for PAH management.
Authors
- Liangdi Xie (ORCID: https://orcid.org/0000-0001-5544-3149)
- Guili Lian (ORCID: https://orcid.org/0000-0001-5909-3991)
- Mohammad Ismail Hajary Sagor (ORCID: https://orcid.org/0009-0005-3843-938X)
- Gufeng Gao (ORCID: https://orcid.org/0000-0001-6448-7215)
- Yan Yan (ORCID: https://orcid.org/0000-0002-8399-4818)
- Li Luo (ORCID: https://orcid.org/0000-0001-7809-6821)
- Ai Chen (ORCID: https://orcid.org/0000-0002-5682-2148)
- Weijun Lin (ORCID: https://orcid.org/0009-0009-2667-0081)
- Hung‐Ju Lin (ORCID: https://orcid.org/0000-0002-4577-7601)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fcvm.2025.1543319
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52