Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis
GR activation may suppress the Th2 immune response triggered by egg antigens by downregulating the expression of the key transcription factors Gata3 and Pparg. While these findings provide insights into a potential complementary therapeutic strategy, further research is necessary to assess the feasibility and safety of targeting GR activation for the treatment of schistosomiasis.
Authors
- Renyong Lin (ORCID: https://orcid.org/0000-0001-6210-4719)
- Tao Sun (ORCID: https://orcid.org/0000-0001-9087-4702)
- Rui Tang (ORCID: https://orcid.org/0000-0002-6950-9580)
- Jin Chu (ORCID: https://orcid.org/0000-0003-4606-6585)
- Xiaojuan Bi (ORCID: https://orcid.org/0000-0002-8287-1138)
- Hui Liu (ORCID: https://orcid.org/0000-0002-7669-9386)
- Liang Li (ORCID: https://orcid.org/0000-0001-9139-5025)
- Ning Yang (ORCID: https://orcid.org/0000-0002-7457-6307)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-1057-4417)
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1518586
- Citations
- 2
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 4.10