Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes

Abstract The construction of optically pure benzyl trifluoromethoxy (OCF 3 ) compounds continues to present challenges due to limited enantioselectivity‐control or the necessity for OCF 3 ‐containing substrates in the only two previous reports. Herein, we have developed a salen‐Co‐catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.