Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes
The construction of optically pure benzyl trifluoromethoxy (OCF<sub>3</sub>) compounds continues to present challenges due to limited enantioselectivity-control or the necessity for OCF<sub>3</sub>-containing substrates in the only two previous reports. Herein, we have developed a salen-Co-catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.
Authors
- Yu‐Xin Luan
- Kang Wu (ORCID: https://orcid.org/0000-0002-9103-4307)
- Ya‐Feng Si (ORCID: https://orcid.org/0000-0003-0369-2295)
- Lei Fang (ORCID: https://orcid.org/0000-0003-3999-7170)
- Pingping Tang
- Li Chen (ORCID: https://orcid.org/0000-0001-8820-1496)
- Fan Zhou
- Yuntao Liu (ORCID: https://orcid.org/0000-0002-8320-8725)
Institutions
- Nankai University (CN)
- Kashi University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1002/anie.202501680
- Citations
- 9
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 7.12