New use of an old drug: mechanism of oseltamivir phosphate inhibiting liver cancer through regulation of lipophagy via NEU1
OP inhibits liver cancer progression by targeting NEU1 and inducing lipophagy through the suppression of PLIN2. Our findings provide new directions on the role of NEU1 in liver cancer and offer latent strategies to address the chemotherapy-induced drug resistance.
Authors
- Weiwei He (ORCID: https://orcid.org/0000-0002-3495-9514)
- Yu Wu (ORCID: https://orcid.org/0000-0002-3435-1074)
- Yuqiu Ge
- Xiaoyu Ma (ORCID: https://orcid.org/0000-0002-8853-5629)
- Yuyu Chen (ORCID: https://orcid.org/0000-0002-5675-4931)
- Hetian Chen (ORCID: https://orcid.org/0000-0003-4505-403X)
- Wenchao Zhang (ORCID: https://orcid.org/0000-0002-6815-7173)
- Peiyu Han (ORCID: https://orcid.org/0000-0002-8753-2426)
- Haixia Zhu
- Yiting He
Institutions
- Jiangnan University (CN)
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Nantong Tumor Hospital (CN)
- Wuxi Fourth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fphar.2025.1556661
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59