Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients
Our study reveals an early characteristic overall T cell dysfunction of pro-inflammatory (IFN-γ, IL-2, IL-17) and immunosuppressive (IL-10) subtypes in polytraumatized patients. Our data indicates that rather the functional capacity of T cells to release cytokines, but not systemic cytokine concentrations can be used to predict outcome post trauma. We assume that the early stimulation of pro- and anti-inflammatory T cells benefits polytraumatized patients. Potentiation of functional IFN-γ release might be achieved by IL-7 administration.
Authors
- Markus Huber‐Lang (ORCID: https://orcid.org/0000-0003-2359-6516)
- Jasmin Maria Bülow (ORCID: https://orcid.org/0009-0009-0671-7698)
- Katharina Maier (ORCID: https://orcid.org/0000-0001-9000-917X)
- Lena-Marie Reichardt
- Christian B. Bergmann (ORCID: https://orcid.org/0000-0003-4390-4248)
- Rebecca Halbgebauer (ORCID: https://orcid.org/0000-0001-8060-2076)
- Florian Gebhard (ORCID: https://orcid.org/0009-0000-3279-8633)
- Borna Relja (ORCID: https://orcid.org/0000-0002-5625-8823)
- Konrad Schuetze (ORCID: https://orcid.org/0000-0002-6607-2539)
- Lisa Wohlgemuth (ORCID: https://orcid.org/0000-0001-5795-812X)
- Marco Mannes (ORCID: https://orcid.org/0009-0003-4875-8275)
- Tobias Jooss
- Bianca Hindelang
- Lönna Süberkrüb
- Kim Lena Hamberger
Institutions
- Universität Ulm (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1538516
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35