Voluntary locomotion induces an early and remote hemodynamic decrease in the large cerebral veins
This initial reduction in HbT within the draining and meningeal veins potentially serves as a "space-saving" mechanism, allowing for large increases in cortical HbT associated with locomotion. Given this mechanism is impacted by disease, it may provide an important target for vascular-based therapeutic interventions.
Authors
- Jason Berwick (ORCID: https://orcid.org/0000-0003-4026-0088)
- Clare Howarth (ORCID: https://orcid.org/0000-0002-6660-9770)
- Kira Shaw
- Beth Eyre (ORCID: https://orcid.org/0000-0001-9261-3776)
- Sheila Francis (ORCID: https://orcid.org/0000-0001-6552-0339)
Institutions
- University of Sheffield (GB)
Publication Details
- Journal
- Neurophotonics
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1117/1.nph.12.s1.s14609
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- UK Research and Innovation
- Medical Research Council