Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II
This study provides a deconvoluted genomic profiling of O-GlcNAc-modified proteins in murine and human cells. Perturbations of O-GlcNAc or RNA Pol II uncover a context-specific reciprocal functional interplay between the transcription machinery and the O-GlcNAc modification.
Authors
- Yulia G. Ermakova (ORCID: https://orcid.org/0000-0002-9020-1943)
- Sofia Rucli (ORCID: https://orcid.org/0000-0002-2004-0785)
- Ana Bošković (ORCID: https://orcid.org/0000-0003-1258-4376)
- Nicolas Descostes (ORCID: https://orcid.org/0000-0001-5599-5808)
- Mathieu Boulard (ORCID: https://orcid.org/0000-0001-5135-8529)
- Urvashi Chitnavis (ORCID: https://orcid.org/0000-0002-0837-3341)
- J. Couturier
Institutions
- European Molecular Biology Organization (DE)
- Heidelberg University (DE)
- European Molecular Biology Laboratory (IT)
Publication Details
- Journal
- Genome biology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s13059-025-03537-2
- Citations
- 3
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- European Molecular Biology Laboratory