Psychoneuroendocrine stress response in female and male youth with major depressive disorder
Results indicate a discrepant stress reactivity in youth with MDD, with increased psychological, but decreased neuroendocrine responses to psychosocial stress. Blunted neuroendocrine stress responses in youth with MDD were found across different neuroendocrine systems and in both females and males with MDD. These novel findings point to a fundamentally changed stress response in youth with MDD irrespective of sex, which may influence successful stress regulation in the affected adolescents.
Authors
- Anka Bernhard (ORCID: https://orcid.org/0000-0001-8864-1360)
- Christine M. Freitag (ORCID: https://orcid.org/0000-0001-9676-4782)
- Nikola Fann
- Anne Martinelli (ORCID: https://orcid.org/0000-0002-7158-9778)
- Andreas G. Chiocchetti (ORCID: https://orcid.org/0000-0002-7329-9985)
- Katharina Ackermann (ORCID: https://orcid.org/0000-0001-6443-7680)
Institutions
- Goethe University Frankfurt (DE)
- Universität Hamburg (DE)
- Frobenius-Institut (DE)
- University Hospital Frankfurt (DE)
- Hochschule Fresenius (DE)
- Frankfurt University of Applied Sciences (DE)
- HAW Hamburg (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal of Child Psychology and Psychiatry
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1111/jcpp.14168
- Citations
- 5
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Seventh Framework Programme