Catastrophic antiphospholipid antibody syndrome provoked by eltrombopag
Antiphospholipid antibody syndrome (APS) may rarely present with isolated thrombocytopenia that may be diagnosed and treated as immune thrombocytopenic purpura. A 32-year-old woman was given eltrombopag (a thrombopoietin receptor agonist) to treat presumed immune thrombocytopenic purpura. She developed catastrophic APS, with multiple ischaemic infarcts, microvascular coronary thrombosis and digital gangrene. She improved after stopping eltrombopag and starting immunotherapy (corticosteroids, intravenous immunoglobulin and rituximab) but was left with significant neurological morbidity.
Authors
- Appaswamy Thirumal Prabhakar
- Angel Miraclin T (ORCID: https://orcid.org/0000-0002-6536-9170)
- Aditya Nair (ORCID: https://orcid.org/0000-0003-4218-4154)
- Ajith Sivadasan (ORCID: https://orcid.org/0000-0001-9949-7878)
- Sanjith Aaron (ORCID: https://orcid.org/0000-0002-5151-1500)
- Harshad Arvind Vanjare (ORCID: https://orcid.org/0000-0002-4321-7221)
- KN Brunda
- Vivek Mathew
- George Abraham Ninan (ORCID: https://orcid.org/0000-0002-6602-4369)
- Burnette Dylan T.
- Leena RV
- Joshi Nutan Damodar
- Yamuna Naik
Institutions
- Christian Medical College, Vellore (IN)
- Christian Medical College (IN)
Publication Details
- Journal
- Practical Neurology
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1136/pn-2025-004512
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77