Exploring diagnostic m6A regulators in primary open-angle glaucoma: insight from gene signature and possible mechanisms by which key genes function
The differentially expressed m6A regulators in TM tissues may serve as potential diagnostic biomarkers for POAG. And, in HTMCs, the expression level of YTHDC2 mRNA was changed under oxidative stress or TGF-β2 intervention, and then exerted its regulation on cell migration and ECM synthesis capability through m6A modification, which may be an important part of the disease process of POAG.
Authors
- Dengming Zhou
- Ziyan Cai (ORCID: https://orcid.org/0000-0001-6139-6932)
- Zhi‐Min Liao (ORCID: https://orcid.org/0000-0001-6361-9626)
- Xuanchu Duan (ORCID: https://orcid.org/0000-0002-3148-1703)
- Li Liao (ORCID: https://orcid.org/0000-0002-3991-0824)
- Xinyue Zhang (ORCID: https://orcid.org/0009-0005-6770-930X)
- Ping Wu (ORCID: https://orcid.org/0000-0003-2664-8502)
- Jiawei Chen (ORCID: https://orcid.org/0000-0002-4874-3474)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-4524-6154)
- Xiaoyu Zhou (ORCID: https://orcid.org/0000-0002-3947-1788)
- Fen Nie
Institutions
- Central South University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12920-025-02123-6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hainan Province