Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains <i>in vitro</i>, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.

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Publication Details

Journal
Frontiers in Nutrition
Published
2025-03-24
DOI
https://doi.org/10.3389/fnut.2024.1501685
Citations
2
Primary Topic
Animal Virus Infections Studies
Type
article
Field-Weighted Citation Impact
2.39
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article

Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

Zhanding Cui, Xingwen Bai, Tong Xu, Hong Yuan et al.
2 citations
Frontiers in Nutrition
Animal Virus Infections Studies
2.39
article

Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

Zhanding Cui, Xingwen Bai, Tong Xu, Hong Yuan, Yuanfang Fu, Yimei Cao, Zengjun Lu, Zaixin Liu, Pinghua Li, Xueqing Ma, Jinlong Wang, Jing Zhang, Kun Li, Qiang Zhang, Kai Li, Jinyi Liu, Zhixun Zhao, Dong Li, Huifang Bao
article en
2 citations

Abstract

This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains <i>in vitro</i>, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.

Frontiers in NutritionVol. 11
Gansu Agricultural University (CN), Hebei North University (CN), Lanzhou Veterinary Research Institute (CN), Chinese Academy of Agricultural Sciences (CN), Lanzhou University (CN)
Reduced inequalities
Openalex Percentile: Top 15%
Animal Virus Infections Studies
2.39
DOIOpen Access PDFOpenAlex
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