Quercetin Improves Hippocampal Neurogenesis in Depression by Regulating the Level of Let-7e-5p in Microglia Exosomes
The inhibitory effect of let-7e-5p in microglial exosomes on depression-associated neurogenesis is mediated through the blockade of the Wnt1/β-catenin signaling pathway, which can be effectively reversed by Quercetin treatment.
Authors
- Qinglai Bian (ORCID: https://orcid.org/0000-0003-3194-7179)
- Min Zhao (ORCID: https://orcid.org/0000-0003-1779-8111)
- Biran Zhu (ORCID: https://orcid.org/0000-0001-7581-2191)
- AnPing Xu
- Ying Xie
- Tongxuan Ouyang
Institutions
- Hubei University of Chinese Medicine (CN)
- Wuhan Ship Development & Design Institute (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s493779
- Citations
- 6
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 7.34
Funders
- Natural Science Foundation of Hubei Province