Hyper-IgE Syndrome: A Case Report with Insights from Bioinformatics Analysis of Key Pathways and Genes
Increased HIES awareness among healthcare providers is crucial for patients with recurrent infections, requiring a multidisciplinary approach. Our study identified IL6, CDH2, and CLDN1 as key factors in HIES progression, suggesting naive B cells and dormant mast cells may be involved.
Authors
- Weihua Han (ORCID: https://orcid.org/0000-0002-9313-0749)
- Jiaqi Fan (ORCID: https://orcid.org/0000-0002-1909-9026)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Juan Li (ORCID: https://orcid.org/0000-0003-0905-7188)
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Guodong Li (ORCID: https://orcid.org/0000-0002-5163-3241)
- Meng-Yu Zhang (ORCID: https://orcid.org/0000-0002-4743-352X)
Institutions
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Qilu Hospital of Shandong University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/idr.s507797
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00