Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling
This study underscores the pivotal role of LOXL1 in activating M1 macrophages through NF-κB and STAT3 signaling, thereby promoting pro-inflammatory cytokine secretion and contributing to OA pathogenesis. LOXL1 holds promise as a potential marker for early diagnosis of OA inflammation and as a novel therapeutic target.
Authors
- Jixian Ye
- Jiahui Mao (ORCID: https://orcid.org/0009-0007-8124-7206)
- Yongbin Ma (ORCID: https://orcid.org/0000-0002-0213-194X)
- Yuepeng Zhou (ORCID: https://orcid.org/0000-0003-2428-4987)
- Wei‐Guo Zhu (ORCID: https://orcid.org/0000-0001-8385-6581)
- Liyue Huo
- Yuyun Jiang
- Shang Wang (ORCID: https://orcid.org/0000-0002-9284-6390)
- Xi Liu (ORCID: https://orcid.org/0000-0002-1901-1506)
- Xuefeng Wang (ORCID: https://orcid.org/0000-0002-5980-6530)
- Zhe Yang (ORCID: https://orcid.org/0009-0002-1556-4936)
- Yanwei Yang
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Jintan People's Hospital (CN)
- Magna International (Canada) (CA)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/itt.s512768
- Citations
- 6
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 4.84