M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis
M2-exos improve pregnancy outcomes in OAPS via the miR-20a-5p/TXNIP/NLRP3 axis, and thus represent as a novel therapeutic approach for aPLs-induced OAPS.
Authors
- Mingyang Xu (ORCID: https://orcid.org/0009-0006-0199-9815)
- Pengzheng Chen
- Qian Liu (ORCID: https://orcid.org/0000-0002-1574-6150)
- Lei Li (ORCID: https://orcid.org/0000-0002-1479-3967)
- Tingting Dong
- Hongyuan Zhang (ORCID: https://orcid.org/0000-0001-5292-5732)
- Xietong Wang (ORCID: https://orcid.org/0000-0001-5169-7838)
- Ning Jiang (ORCID: https://orcid.org/0000-0003-0794-7996)
- Qingfeng Lv (ORCID: https://orcid.org/0000-0003-1570-6308)
- Die Jing
- Ruiheng Huo
Institutions
- Shandong Provincial Hospital (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.lfs.2025.123561
- Citations
- 4
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province