Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways
Our study reveals that APS exert significant protective effects against ATO-induced apoptosis in BMSCs. The mechanisms involve suppressing ROS generation, maintaining mitochondrial membrane stability, enhancing cell viability, migration, and proliferation, as well as inhibiting Jnk and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways. The findings highlight potential molecular targets and novel strategies for the clinical prevention and treatment of ATO-related toxicity <b><i>.</i></b>
Authors
- Wenyi Qi
- Fan Yang (ORCID: https://orcid.org/0000-0003-4676-3778)
- Juan Tang (ORCID: https://orcid.org/0000-0002-0098-0403)
- Qingchao Wu
- Feng Wu (ORCID: https://orcid.org/0000-0003-3989-0509)
- Yuan Li (ORCID: https://orcid.org/0000-0001-9942-0803)
- Y. Liu (ORCID: https://orcid.org/0009-0000-2326-1113)
- Jingwen Ne
- Djibril Bamba
- Ying Su (ORCID: https://orcid.org/0000-0001-8322-0655)
- Fengda Li (ORCID: https://orcid.org/0000-0002-7322-422X)
- Suping Duan (ORCID: https://orcid.org/0000-0002-4835-6888)
- Jingwei Liu
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-5249-2201)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-7742-1335)
- Zheng Zhang (ORCID: https://orcid.org/0000-0001-8433-1568)
- Yang Li (ORCID: https://orcid.org/0000-0002-1074-3735)
- Wenbo Wang (ORCID: https://orcid.org/0000-0003-2860-6218)
- Wei Wu
- Hongbo Wang (ORCID: https://orcid.org/0000-0003-1591-297X)
- Yang Lei
Institutions
- Harbin Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Heilongjiang Academy of Sciences (CN)
- Suzhou Research Institute (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Education Department of Heilongjiang Province (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
Publication Details
- Journal
- Chinese Herbal Medicines
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.chmed.2025.03.007
- Primary Topic
- Arsenic contamination and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00