Histopathological evaluation of viscoelastic POSS administered subcutaneously using a rat model

POSS vesicles formed after injection and remained pliable over 180 days. POSS complexed with Perylene dye could be imaged over 4 weeks showing lack of systemic mobility. Over the course of 180 days, POSS triggered a foreign body response with low- grade inflammation. The high viscosity nature of POSS resulted in the formation of a dense capsule preventing the material migration. <b>Conclusion</b>: POSS is encapsulated with connective tissue without long-term inflammatory cells or granuloma cell formation for 180 days in rats.