ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma
Collectively, we demonstrate that LLPS and transcriptional regulation form an oncogenic double positive feedback loop between ASPM and FOXM1. This provides a rationale strategy to treat HCC by targeting this mechanism.
Authors
- Jianyong Sun (ORCID: https://orcid.org/0000-0003-2915-9114)
- Huilong Yin
- Xiang Zhang (ORCID: https://orcid.org/0000-0002-9900-3329)
- Pu Gao (ORCID: https://orcid.org/0000-0002-5328-9755)
- Yongkang Liu (ORCID: https://orcid.org/0000-0002-0011-322X)
- Ningbo Wang (ORCID: https://orcid.org/0000-0003-1622-7819)
- Jipeng Li
- Ke Wang (ORCID: https://orcid.org/0009-0004-9852-3842)
- Jun Liu (ORCID: https://orcid.org/0000-0002-7508-9287)
- Xiaochen Ding
- Lin Li (ORCID: https://orcid.org/0000-0002-5050-0762)
- Yu Jiang (ORCID: https://orcid.org/0009-0005-6998-759X)
- Xunliang Jiang
Institutions
- Chinese Academy of Sciences (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- National Clinical Research Center for Digestive Diseases (CN)
- Xi'an Medical University (CN)
- Institute of Biophysics (CN)
- Central Hospital of Wuhan (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Tang Du Hospital (CN)
- Xijing Hospital (CN)
- Henan Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1186/s13059-025-03526-5
- Citations
- 6
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.84